The mission of the Tri-State Early College STEM Collaborative is to inspire all students to achieve personal excellence, pursue world class STEM-M education, and become self-directed life-long learners. The Tri-State Early College STEM Collaborative has been conceptualized through a shared vision among the region’s business community, major employers, workforce development organizations, civic and government agencies, nonprofit organizations, and institutions of higher education. The founding partners have committed their efforts to the creation of a school, opening in the fall of 2017, with a focus on science, technology, engineering, mathematics, and medicine – as the medical field is the largest employer in the Tri-State region. The school will intentionally connect community stakeholders with learners, faculty, and staff who will collectively identify concepts of health, wellness, medical treatment, and sustainable change that will initiate personal engagement and promote student agency – ultimately providing students with opportunities for meaningful learning to acquire new knowledge and problem-solving skills through the process of designing solutions to real-world problems. The school is not intended to be merely an educational alternative to the area’s existing high schools, but a long-term economic development strategy to ensure the students of the region are prepared for college and well-paying, lasting careers.